VIRUSLARNING ONKOGENEZ BILAN BOG’LIQLIGI: HPV, EBV VA HBV MISOLLARI
Keywords:
Onkogen viruslar deb ataladigan bu patogenlar hujayralarning genetik materialiga ta'sir o'tkazib, kontrolsiz ko'payishga, apoptoz (dasturlangan o'lim) mexanizmlarining inaktivatsiyasiga va oxir-oqibat malign transformatsiyaga olib keladi. Ushbu viruslar o'z onkogen oqsillarini kodlashi yoki hujayra proto-onkogenlarini faollashtirishi orqali saraton rivojlanishiga sabab bo'ladi.Abstract
Mavzuning dolzarbligi. Saraton kasalligi jahon miqyosidagi eng muhim tibbiy muammolardan biri bo'lib, har yili millionlab odamning hayotiga xavf solmoqda. Xalqaro saraton tadqiqot agentligi (IARC) ma'lumotlariga ko'ra, barcha saraton holatlari ichida 15-20% viral infeksiyalar bilan bevosita bog'liq. Bu raqam ayniqsa quyi va o'rta daromadli mamlakatlarda yuqori ko'rsatkichlarga ega.
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