YUQORI NAFAS YO‘LLARI KASALLIKLARI BILAN OG‘RIGAN O‘SMIR QIZLARDA YALLIG‘LANISH OMILLARINING MARKAZIY ASAB TIZIMI VA GORMONAL FONGA TA’SIRI
Keywords:
o‘smir qizlar, yuqori nafas yo‘llari kasalliklari, surunkali tonzillit,faringit,rinosinusit, yallig‘lanish omillari, sitokinlar, IL-1β, IL-6, TNF-α, CRP, markaziy asab tizimi, gipotalamus, bachadon,tuxumdon,GnRH, kisspeptin, FSH, LH, estradiol, progesteron, hayz sikli.Abstract
10-18 yosh oralig`i ya`ni o`smirlik davri gipotalamo-gipofizar-tuxumdon tizimining funksional yetilishi bilan kechib boradigan muhim biologik davr hisoblanadi. Ushbu vaqt oralig`ida qayta-qayta infeksion-yallig‘lanish bilan kechadigan kasalliklar, ya`ni, yuqori nafas yo‘llari kasalliklari:surunkali tonzillit,faringit,rinosinusit,gaymorit va shu kabi kasalliklar organizmning immun, asab va endokrin tizimlari o‘rtasidagi aloqalarga ta’sir ko‘rsatadi.. Yallig‘lanish jarayoni boshlanganda interleykin-1β (IL-1β), interleykin-6 (IL-6), o‘sma nekrozi omili-α (TNF-α) va C-reaktiv oqsil (CRP) kabi mediatorlarning faollashuvi kuzatiladi bu esa markaziy asab tizimi, gipotalamo-gipofizar-buyrak usti bezi va gipotalamo-gipofizar-tuxumdon o‘qlarining fiziologik faoliyatiga ta`sir qiladi.Oxirgi yillarda to`plangan ma’lumotlarga ko‘ra, yallig‘lanish omillari GnRH neyronlari hamda ularni boshqaruvchi kisspeptin tizimining faoliyatini o‘zgartirib, gonadotropinlar sekretsiyasi va reproduktiv tizim rivojlanishining va funksiyaning buzilishiga olib keladi.
Quyidagi maqolada yuqori nafas yo‘llari kasalliklari bilan og‘rigan o‘smir qizlarda yallig‘lanish mediatorlarining markaziy asab tizimiga ta’siri, stress tizimining faollashuvi, GnRH–FSH/LH mexanizmlarining o‘zgarishi hamda tuxumdon steroidogeneziga ta’siri tahlil qilindi. Shuningdek, yallig‘lanish faktorlari, gormonal fon va hayz sikli buzilishlari o‘rtasidagi patogenetik bog‘liqlikni o‘rganish istiqbollari ko‘rsatildi.
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