EARLY BIOMARKERS OF NEURODEVELOPMENTAL DISORDERS IN PRETERM INFANTS: A PROSPECTIVE MULTIMODAL COHORT STUDY
Keywords:
A prospective cohort study was conducted among preterm infants born at <32 weeks’ gestation and admitted to a tertiary neonatal intensive care unit.Abstract
Background
Preterm birth remains one of the strongest risk factors for neurodevelopmental disorders (NDDs), including cerebral palsy, autism spectrum disorder, and cognitive impairment. Early identification of high-risk infants through reliable biomarkers may enable timely intervention and improve long-term outcomes. However, clinically validated early predictors remain insufficiently integrated into neonatal practice.
References
Volpe JJ, Brain injury in premature infants, Lancet Neurology, 2019, 18(1):110-124.
Glass HC, Early biomarkers of neonatal brain injury, Pediatrics, 2018, 142(6):e20180642.
Back SA, White matter injury in preterm infants, Nature Reviews Neurology, 2017, 13(6):331-345.
O’Shea TM, Neurodevelopmental outcomes after preterm birth, Journal of Pediatrics, 2020, 218:6-12.
Murray DM, aEEG monitoring in neonates, Clinical Neurophysiology, 2016, 127(1):1-11.
Inder TE, MRI biomarkers in preterm brain injury, Pediatric Research, 2018, 84(3):372-380.
Hintz SR, Neurodevelopmental follow-up of extremely preterm infants, Pediatrics, 2020, 145(2):e20191505.
Hagberg H, Inflammation and brain injury in preterm infants, Nature Reviews Neurology, 2015, 11(4):192-208.
Ment LR, Imaging predictors of outcome, Neurology, 2017, 88(9):890-898.
Doyle LW, Long-term outcomes of prematurity, Seminars in Fetal & Neonatal Medicine, 2019, 24(2):101-107.
Glass HC, Seizure biomarkers in neonates, Neurology, 2017, 88(10):978-986.
Thompson DK, Diffusion MRI in neonatal brain development, NeuroImage, 2019, 185:112-123.
Spittle AJ, Early intervention after preterm birth, Early Human Development, 2018, 125:1-7.
Ahearne CE, Predictive modeling in neonatal neurology, Frontiers in Neurology, 2021, 12:645321.
Anderson PJ, Neurobehavioral outcomes of preterm infants, Lancet Child & Adolescent Health, 2020, 4(9):713-724.
