HYPOXIC-ISCHEMIC BRAIN INJURY IN NEONATES: NEUROPROTECTIVE APPROACHES AND OUTCOMES IN THE ERA OF MULTIMODAL CARE
Keywords:
We present a full-length scientific manuscript framed as a prospective clinical research protocol and outcomes-oriented analytic model applicable to tertiary neonatal care.Abstract
Neonatal hypoxic-ischemic encephalopathy (HIE) remains a leading cause of neonatal mortality and lifelong neurodevelopmental disability worldwide. Although therapeutic hypothermia (TH) is an established neuroprotective intervention for term and near-term infants with moderate-to-severe HIE, a substantial proportion of cooled infants still experience death or significant impairment, underscoring the need for optimized neuroprotective bundles and validated adjunctive therapies.
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