JIGARDA GORMONLARNI ZARARSIZLANTIRISH KLINIK AHAMIYATI.
Keywords:
jigar, gormonlar, zararsizlantirish, metabolizm, detoksikatsiya, gepatotsit, endokrin tizim, homeostaz, jigar yetishmovchiligi.Abstract
Ushbu maqolada jigarning gormonlarni metabolizm qilish va zararsizlantirishdagi fiziologik hamda klinik ahamiyati yoritilgan. Jigar organizmdagi steroid, qalqonsimon bez va peptid gormonlarining biologik faolligini boshqarishda asosiy organlardan biri hisoblanadi. Gepatotsitlarda yuz beradigan oksidlanish, kon’yugatsiya va biotransformatsiya jarayonlari orqali ortiqcha gormonlar parchalanib, organizmdan chiqariladi. Jigar faoliyatining buzilishi gormonal muvozanatning izdan chiqishiga, endokrin va metabolik kasalliklarning rivojlanishiga sabab bo‘lishi mumkin. Maqolada jigar yetishmovchiligi, sirroz va gepatitlarda kuzatiladigan gormonal o‘zgarishlarning klinik ahamiyati ham tahlil qilingan. Tadqiqot natijalari jigarning detoksikatsion faoliyati organizm homeostazini saqlashda muhim o‘rin tutishini ko‘rsatadi.
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